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Indications for citrulline supplementation include malnutrition associated with intestinal failure, aging and sarcopenia, and cardiovascular conditions benefitting from enhanced NO production, including ED.6 In fact, studies of healthy volunteers show that oral citrulline supplementation raises blood arginine levels more effectively than arginine supplementation itself.32 Other indications include sickle cell anemia, hypertension, hyperlipidemia, diabetes, immunomodulation, arginase-associated T cell dysfunction, cancer, Alzheimer’s disease, improving aerobic function and energy production, urea cycle disorders, some intestinal pathologies, and as an antioxidant.7

L Citrulline (Amino Acid)


    In a single blind, short-term study of men with ED (erection hardness score of 3 out of 4), L-citrulline was given at dose of 1.5 g per day for a month. It was concluded that citrulline was safe and psychologically well-accepted, and reported as very satisfying to the patients. Although less effective than phosphodiesterase type-5 enzyme inhibitors, L-citrulline supplementation was associated with an improvement in erection hardness score, from 3 to 4.


  • Disclaimer: The author makes no guarantees as to the curative effect of any herb or tonic on this website, and no visitor should attempt to use any of the information herein provided as treatment for any illness, weakness, or disease without first consulting a physician or health care provider. Pregnant women should always consult first with a health care professional before taking any treatment.