Indications for citrulline supplementation include malnutrition associated with intestinal failure, aging and sarcopenia, and cardiovascular conditions benefitting from enhanced NO production, including ED.6 In fact, studies of healthy volunteers show that oral citrulline supplementation raises blood arginine levels more effectively than arginine supplementation itself.32 Other indications include sickle cell anemia, hypertension, hyperlipidemia, diabetes, immunomodulation, arginase-associated T cell dysfunction, cancer, Alzheimer’s disease, improving aerobic function and energy production, urea cycle disorders, some intestinal pathologies, and as an antioxidant.7
L Citrulline (Amino Acid)
CITRULLINE IN ERECTILE DYSFUNCTION
In a single blind, short-term study of men with ED (erection hardness score of 3 out of 4), L-citrulline was given at dose of 1.5 g per day for a month. It was concluded that citrulline was safe and psychologically well-accepted, and reported as very satisfying to the patients. Although less effective than phosphodiesterase type-5 enzyme inhibitors, L-citrulline supplementation was associated with an improvement in erection hardness score, from 3 to 4.
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